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10.1038/s42003-019-0587-z Summary Keywords GMP synthetase, CTP synthetase, asparagine synthetase, NAD + synthetase, FGAS, carbamoyl phosphatase synthetase, activity regulation, ammonia tunnel Citation Zhu W, Nardone AJ and Pearce LA (2024) Advances in human glutamine-hydrolyzing synthetases and their therapeutic potential